Use of 2-Hydroxypropyl-β-cyclodextrin as a Solubilizing and Stabilizing Excipient for Protein Drugs
✍ Scribed by Marcus E. Brewster; Maninder S. Hora; James W. Simpkins; Nicholas Bodor
- Book ID
- 110343096
- Publisher
- Springer US
- Year
- 1991
- Tongue
- English
- Weight
- 722 KB
- Volume
- 08
- Category
- Article
- ISSN
- 0724-8741
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📜 SIMILAR VOLUMES
Sustained-release formulations such as hydroxypropyl methylcellulose (HPMC)based hydrophilic matrix tablets of poorly water-soluble drugs often result in incomplete release because of the poor solubility and dissolution rate of the drug in the hydrophilic matrix. Sulfobutylether-b-cyclodextrins ((SB
The objective of this work was to demonstrate that the incorporation of sulfobutylether-beta-cyclodextrin, (SBE)(7M)-beta-CD, results in the complete and sustained release of a sparingly water-soluble drug, prednisolone (PDL) from controlled porosity-osmotic pump pellets (CP-OPP). PDL and CD were pr