No effective medical therapy is currently available for primary sclerosing cholangitis (PSC). Ursodeoxycholic acid (UDCA) improves liver enzymes, but its effect on liver histology is controversial. Metronidazole (MTZ) prevents PSC-like liver damage in animal models and reduces intestinal permeabilit
Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo-controlled trial
✍ Scribed by Ulrich Beuers; Ulrich Spengler; Wolfgang Kruis; ülker Aydemir; Baldur Wiebecke; Walter Heldwein; Marlene Weinzierl; Gerd R. Pape; Tilman Sauerbruch; Gustav Paumgartner
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 855 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0270-9139
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Previous controlled trials are inconclusive regarding the efficacy of ursodeoxycholic acid (UDCA) for treating primary sclerosing cholangitis (PSC). One hundred fifty adult patients with PSC were enrolled in a long-term, randomized, double-blind controlled trial of highdose UDCA (28-30 mg/kg/day) ve
One hundred fifty-one patients with primary biliary cirrhosis (PBC) grouped into four strata based on entry serum bilirubin (<2 mg/dL vs. 2 mg/dL or greater) and liver histology (stages I, 1 1 vs. stages 111, IV-Ludwig criteria) were randomized within each stratum to ursodiol or placebo given in a s
To evaluate the efficacy of ursodeoxycholic acid as adjunctive therapy in type 1 autoimmune hepatitis, 37 patients who had experienced treatment failure, repeated relapse, or incomplete response were randomized to ursodeoxycholic acid (13-15 mg/kg daily) or placebo for 6 months in addition to their