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High-dose ursodeoxycholic acid in the treatment of primary sclerosing cholangitis: Throwing the urso out with the bathwater?

โœ Scribed by Roger W. Chapman


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
63 KB
Volume
50
Category
Article
ISSN
0270-9139

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Previous controlled trials are inconclusive regarding the efficacy of ursodeoxycholic acid (UDCA) for treating primary sclerosing cholangitis (PSC). One hundred fifty adult patients with PSC were enrolled in a long-term, randomized, double-blind controlled trial of highdose UDCA (28-30 mg/kg/day) ve

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Ursodeoxycholic acid (UDCA) is a safe and effective medical therapy for most patients with primary biliary cirrhosis (PBC). However, some patients show an incomplete response to UDCA therapy. Treatment with corticosteroids may be of benefit although at the expense of systemic side effects. Budesonid