Ursodeoxycholic acid for primary sclerosing cholangitis
✍ Scribed by Chazouillères, Olivier; Poupon, Raoul; Capron, Jean-Pierre; Metman, Etienne-Henry; Dhumeaux, Daniel; Amouretti, Michel; Couzigou, Patrice; Labayle, Denis; Trinchet, Jean-Claude
- Book ID
- 121997104
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 220 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0168-8278
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📜 SIMILAR VOLUMES
No effective medical therapy is currently available for primary sclerosing cholangitis (PSC). Ursodeoxycholic acid (UDCA) improves liver enzymes, but its effect on liver histology is controversial. Metronidazole (MTZ) prevents PSC-like liver damage in animal models and reduces intestinal permeabilit
Previous controlled trials are inconclusive regarding the efficacy of ursodeoxycholic acid (UDCA) for treating primary sclerosing cholangitis (PSC). One hundred fifty adult patients with PSC were enrolled in a long-term, randomized, double-blind controlled trial of highdose UDCA (28-30 mg/kg/day) ve