Conversion of testosterone (T) to dihydrotestosterone (DHT) in genital tissue is catalysed by the enzyme 5a-reductase 2, which is encoded by the SRD5A2 gene. The potent androgen DHT is required for full masculinization of the external genitalia. Mutations of the SRD5A2 gene inhibit enzyme activity,
✦ LIBER ✦
URINARY STEROID METABOLITES IN SUBJECTS WITH MALE PSEUDOHERMAPHRODITISM DUE TO 5α-REDUCTASE DEFICIENCY
✍ Scribed by R. E. PETERSON; JULIANNE IMPERATO-McGINLEY; T. GAUTIER; C. SHACKLETON
- Book ID
- 114718281
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 601 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0300-0664
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