Urinary histamine in severe atopic dermatitis
β Scribed by H. Overgaard Petersen; J. Thormann; H. Zachariae
- Publisher
- Springer-Verlag
- Year
- 1979
- Tongue
- English
- Weight
- 148 KB
- Volume
- 264
- Category
- Article
- ISSN
- 0340-3696
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β¦ Synopsis
Urinary histamine was studied in 11 patients with severe atopic dermatitis and 17 controls, as well as in seven atopics prior to and 6 months following hyposensitization. No statistically significant differences were found between the groups. Urinary histamine seems to be of no value as an indicator of disease activity in atopic dermatitis.
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Leukotriene synthesis may be increased in a variety of inflammatory diseases. Urinary leukotriene E4 is a stable metabolite of leukotrienes C4 and D4 which has previously been found to be increased in exacerbations of severe asthma and after antigen inhalation. Levels of urinary LTE4 in seven patien
## Background: Synthesis of cysteinyl leukotrienes (lts) is known to play a part in the pathogenesis of inflammatory diseases. ## Objectives: To define the involvement of cysteinyl lts in atopic dermatitis (ad). ## Methods: Synthesis of cysteinyl lts was assessed in patients with ad and healthy
We determined the histamine content in the skin of 22 adults with atopic dermatitis, one patient with hyper-IgE-syndrome, and 20 controls by the enzymatic double isotope assay. In addition, we performed a pilot study of histamine degradation in the skin. We tested, furthermore, the releasability of