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Increased urinary leukotriene E4 excretion in patients with atopic dermatitis

โœ Scribed by T. Hishinuma; N. Suzuki; S. Aiba; H. Tagami; M. Mizugaki

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
352 KB
Volume
144
Category
Article
ISSN
0007-0963

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โœฆ Synopsis

Background:

Synthesis of cysteinyl leukotrienes (lts) is known to play a part in the pathogenesis of inflammatory diseases.

Objectives:

To define the involvement of cysteinyl lts in atopic dermatitis (ad).

Methods:

Synthesis of cysteinyl lts was assessed in patients with ad and healthy volunteers by measuring urinary lte4, a useful index of systemic cysteinyl lt synthesis, using liquid chromatography/tandem mass spectrometry.

Results:

Mean +/- sd urinary lte4 levels in patients with ad (125 +/- 69 pg mg(-1) creatinine, n = 20) were significantly higher (p < 0.01) than in healthy volunteers (60 +/- 19 pg mg(-1) creatinine, n = 17). a significant correlation between urinary lte4 and total serum ige levels in patients with ad was observed (r = 0.643, p < 0.05).

Conclusions:

Our findings demonstrate an enhanced synthesis of cysteinyl lts in patients with ad and suggest that cysteinyl lts are involved in the pathophysiology of ad.

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