Urinary excretion of phenobarbitone and its metabolites in chronically treated patients

✍ Scribed by I. Bernus; R. G. Dickinson; W. D. Hooper; M. J. Eadie

• Publisher: Springer
• Year: 1994
• Tongue: English
• Weight: 305 KB
• Volume: 46
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00191914

✦ Synopsis

The elimination of phenobarbitone (PB) was studied in 14 chronically treated epileptic patients under steady state conditions. PB, [S]-PB-N-glucoside ( [S]-PB-N-G) and p-hydroxy-PB (p-OH-PB) were assayed in urine by a HPLC method.

Some 57 % of the daily dose was recovered in urine, 14 % as [S]-PB-N-G, 16 % as p-OH-PB (conjugated plus non-conjugated) and 27 % as unaltered PB.

Thus PB-N-G formation contributed significantly to the elimination of PB during long-term administration of the drug, and there was reason to suspect that some of the PB-N-G formed may have already been degraded to untraced products before excretion from the body.