Alteration in de novo pyrimidine biosynt
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Ringer, David P. ;Howell, Boyd A. ;Etheredge, Janet L.
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Article
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1991
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John Wiley and Sons
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English
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## Abstract Pyrazofurin, a pyrimidine nucleoside analogue with antineoplastic activity, inhibits cell proliferation and DNA synthesis in cells by inhibiting uridine 5β²βphosphate (UMP) synthase. It has been previously shown in concanavalin A (con A)βstimulated guinea pig lymphocytes (23) that pyrazo