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In vitro inhibition of Plasmodium falciparum by pyrazofurin, an inhibitor of pyrimidine biosynthesis de novo

✍ Scribed by Haydn V. Scott; Annette M. Gero; William J. O'Sullivan


Book ID
113260074
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
650 KB
Volume
18
Category
Article
ISSN
0166-6851

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## Abstract Pyrazofurin, a pyrimidine nucleoside analogue with antineoplastic activity, inhibits cell proliferation and DNA synthesis in cells by inhibiting uridine 5′‐phosphate (UMP) synthase. It has been previously shown in concanavalin A (con A)‐stimulated guinea pig lymphocytes (23) that pyrazo