𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Uracil- and thymine-substituted thymidine and uridine derivatives

✍ Scribed by Anna M. Costa; Montserrat Faja; Jaume Farràs; Jaume Vilarrasa

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
262 KB
Volume
39
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The four possible 3'-uracil-l-yl and 3'-thymin-l-yl derivatives of 3'-deoxythymidine and the four analogous derivatives of 2'-deoxyuridine have been synthesised from thymidine and uridine, respectively. Advantages of the 2-(methoxycarbonyl)vinyl group to prevent the formation of anhydronueleosides and of SnCI2/PhSH/Et3N in relation to H2/Pd for the reduction of most azido groups are disclosed.

📜 SIMILAR VOLUMES

Synthesis of O4-p-nitrophenylethyl thymi
Synthesis of O4-p-nitrophenylethyl thymidine and uridine derivatives
✍ Bernd S. Schulz; Wolfgang Pfleiderer 📂 Article 📅 1983 🏛 Elsevier Science 🌐 French ⚖ 188 KB

## 04-Protection in thymidine and uridine derivatives has been achieved by the p-nitrophenylethyl group in a silver-ion catalysed alkylation reaction to form valuable building blocks for oligonucleotides syntheses.