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Uptake of cationized ferritin by colonic epithelium

✍ Scribed by W. McA. Barbour; D. Hopwood

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 779 KB
Volume: 139
Category: Article
ISSN: 0022-3417
DOI: 10.1002/path.1711390208

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Guinea‐pig, rat and mouse were used in this electron microscopic study to demonstrate endocytosis in absorptive and goblet cells of the surface epithelium of the colon. Cationised ferritin was used as the electron dense tracer which attached in vivo to negatively charged membrane components. Both coated and uncoated vesicles entered the cells. The major pathway for the vesicles was to the secondary lysosomes and occurred within 10–30 min.

This demonstrates a new pathway of absorption in the adult rodent colon with potential for the uptake of macromolecules. It may provide new clues to the immunology, physiology and pathology of the tissue.

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