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Organic cation uptake by a cultured renal epithelium

✍ Scribed by T. Dwight McKinney; Catherine DeLeon; K. Vincent Speeg Jr.

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
808 KB
Volume
137
Category
Article
ISSN
0021-9541

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✦ Synopsis

Several organic cations are actively transported by proximal renal tubules by mediated processes across both the apical and basolateral cell membranes. In order to evaluate this transport system in a cultured renal epithelium, uptake of 'H-tetraethylammonium (TEA) across the apical membrane was measured in LLCPK, cells, a cell line with several characteristics of proximal tubules. 3H-TEA progressively entered these cells and reached a near-steady state by 30 min. Three-minute uptake was saturable with an apparent Vmax of 1,669 % 129 fmolesipg DNA and apparent Km of 34.0 * 3.4 pM. 'H-TEA uptake was

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