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Uptake of Amino Acids by Brain Microvessels Isolated from Rats after Portacaval Anastomosis

โœ Scribed by Patrizia Cardelli-Cangiano; Carlo Cangiano; J. Howard James; Bengt Jeppsson; William Brenner; Josef E. Fischer


Book ID
111171415
Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
568 KB
Volume
36
Category
Article
ISSN
0022-3042

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Uptake of propranolol by microvessels is
โœ Atsushi Kurihara; Hiroshi Suzuki; Yasufumi Sawada; Yuichi Sugiyama; Tatsuji Iga; ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 552 KB

To study the transport system of propranolol (PL), a basic drug, in the blood-brain barrier, the uptake of PL into isolated bovine brain microvessels was investigated. The uptake of PL was a concentrative one via saturable process (Km = 42.5 microM) that was decreased by hypothermia (Q10 = 2.2), but