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Uptake and cytotoxicity of 9-methoxy-N2-methylellipticinium acetate in human brain and non-brain tumor cell lines

✍ Scribed by Susan Kenney; David T. Vistica; Hedda Linden; Michael R. Boyd

Book ID: 115783702
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 826 KB
Volume: 49
Category: Article
ISSN: 0006-2952
DOI: 10.1016/0006-2952(94)00471-w

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## Abstract The DNA repair protein __O__^6^‐methylguanine‐DNA methyltransferase (MGMT) has been implicated in resistance of human brain tumors to alkylating agents. We observed that 14 human medulloblastoma‐ and gliomaderived cell lines differ in sensitivity to the methylating agent __N__‐methyl‐__