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Upregulation ofIGF2is associated with an acquired resistance forcis-diamminedichloroplatinum in human head and neck squamous cell carcinoma

✍ Scribed by Takenori Ogawa; Kazumi Ogawa; Kiyoto Shiga; Toru Furukawa; Hiroki Nagase; Sho Hashimoto; Toshimitsu Kobayashi; Akira Horii


Book ID
106084093
Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
501 KB
Volume
267
Category
Article
ISSN
0302-9530

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## Abstract It has been previously demonstrated that human carcinomas express interleukin‐2 receptor (IL‐2R) Ξ±, Ξ², and Ξ³ chains. The Ξ² and Ξ³ chains of IL‐2R have intermediate binding affinity for IL‐2 and are responsible for the intracellular signaling cascades after IL‐2 stimulation. IL‐2RΞ± lacks