Loss of chromosomes 3p, 4q, and 11q is associated with radiation resistance in patients with head and neck squamous cell carcinoma
โ Scribed by Daniel J. Lee; Shelly McQuone; Duane Sewell; Wayne Koch; David Sidransky; William Westra
- Book ID
- 117402853
- Publisher
- SAGE Publications
- Year
- 1997
- Tongue
- English
- Weight
- 119 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0194-5998
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## Abstract About 45% of head and neck squamous cell carcinomas (HNSCC) are characterized by amplification of chromosomal band 11q13. This amplification occurs by a breakageโfusionโbridge (BFB) cycle mechanism. The first step in the BFB cycle involves breakage and loss of distal 11q, from __FRA11F_
## Abstract Eight cytogenetically characterized head and neck squamous cell carcinomas (HNSCCs) with __CCND1__ amplification in the form of a homogeneously staining region (hsr) in 11q13 were studied by COBRA FISH and FISH with specific probes to identify and characterize chromosomal segments added