Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas
β Scribed by Davut Pehlivan; Esra Gunduz; Mehmet Gunduz; Hitoshi Nagatsuka; Levent Bekir Beder; Beyhan Cengiz; Rosario S. Rivera; Kunihiro Fukushima; Sukru Palanduz; Sukru Ozturk; Noboru Yamanaka; Kenji Shimizu
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 378 KB
- Volume
- 134
- Category
- Article
- ISSN
- 1432-1335
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Frequent loss of a specific chromosomic region in cancers is often associated with inactivation of a tumor-suppressor gene. The long arm of chromosome 10 is deleted in several types of tumor, among them squamous-cell carcinomas of the head and neck (HNSCC). To determine the role of 10q deletions in
Tumor suppressor genes play an important role in normal growth regulation. Loss or inactivation of these genes has been implicated in the development of squamous cell cancer and progression of neoplasia. Previous studies in our laboratories have implicated chromosome 18 long-arm deletions as a possi