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Upregulation of TRAIL-R2 is not involved in HDACi mediated sensitization to TRAIL-induced apoptosis

✍ Scribed by Inoue, S; Twiddy, D; Dyer, M J S; Cohen, G M

Book ID: 110017273
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 96 KB
Volume: 13
Category: Article
ISSN: 1350-9047
DOI: 10.1038/sj.cdd.4401977

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## Abstract Histone‐deacetylase (HDAC) inhibitors (HDACi) can block proliferation and induce intrinsic apoptosis in human papillomavirus (HPV)‐positive cervical carcinoma cells, independently of copy number and integration locus of the viral DNA. Using HPV18‐positive HeLa cells as model systems, we