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Low concentrations of doxorubicin sensitizes human solid cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-receptor (R) 2-mediated apoptosis by inducing TRAIL-R2 expression

✍ Scribed by Xiu-Xian Wu; Xing-Hua Jin; Yu Zeng; Ahmed Mamdouh Abd El Hamed; Yoshiyuki Kakehi


Book ID
108584027
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
628 KB
Volume
98
Category
Article
ISSN
1347-9032

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## Abstract Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) has been shown to induce apoptosis in numerous transformed cell lines but not in most normal cells. Although this selectivity offers a potential therapeutic application in cancer, not all cancers are sensitive to TRAIL‐medi