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Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP

✍ Scribed by Robinson, Ari; Grösgen, Sven; Mett, Janine; Zimmer, Valerie C.; Haupenthal, Viola J.; Hundsdörfer, Benjamin; P. Stahlmann, Christoph; Slobodskoy, Yulia; Müller, Ulrike C.; Hartmann, Tobias; Stein, Reuven; Grimm, Marcus O. W.


Book ID
124074548
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
641 KB
Volume
13
Category
Article
ISSN
1474-9718

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To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellular concentration of amyloid beta-protein (A beta) ending at A beta 42(43) in vivo, we performed a blinded comparison