✦ LIBER ✦

Upper respiratory tract tumors induced in syrian hamsters by N-methyl-N-nitrosourea

✍ Scribed by Katherine McD. Herrold

Publisher: John Wiley and Sons
Year: 1970
Tongue: French
Weight: 507 KB
Volume: 6
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910060208

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Syrian hamsters were treated weekly for 2 1/2 months by intratracheal instillation of N‐nitroso‐N‐methylurea (NMU). All the animals, with the exception of one that survived to 11 months of age, were killed between 5 and 7 months because of severe respiratory insufficiency. Tumors, often multicentric in origin and frequently at different sites, developed in the nasopharyngeal tube, pharynx, larynx, trachea, bronchi, esophagus and forestomach. Histologically the tumors were epidermoid carcinomas. No distant metastases were observed.

The results indicate that NMU exerts a strong local carcinogenic action when applied topically to the mucosa of the upper respiratory tract of Syrian hamsters. The wide spectrum of lesions, benign and malignant tumors, that occur following parenteral administration of NMU were not seen.

📜 SIMILAR VOLUMES

Alteration of gene expression in rat mam

Alteration of gene expression in rat mammary tumors induced by N-methyl-N-nitrosourea

✍ Lindon H. Young; Xiaoqi Yang; Jeffrey M. Voigt 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 947 KB

Rodents are susceptible to the effects of chemical carcinogens and have been widely used in the study of mammary-gland carcinogenesis. However, little information is available regarding specific phenotypic changes that occur during mammary-gland carcinogenesis. In this study, subtraction hybridizati

ras Oncogene activation in mammary carci

ras Oncogene activation in mammary carcinomas induced by n-methyl-n-nitrosourea in copenhagen rats

✍ Shi-Jiang Lu; Michael C. Archer 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 590 KB

## Abstract The occurrence of Ha‐__ras__ and Ki‐__ras__ oncogenes was investigated in mammary tumors produced by treating genetically resistant Copenhagen (Cop) rats with __N__‐methyl‐__N__‐nitrosourea. G^35^A codon 12 mutations in both Ha‐__ras__ and Ki‐__ras__ genes were analyzed by a polymerase

HGPRT mutation induction by N-ethyl-N-ni

HGPRT mutation induction by N-ethyl-N-nitrosourea as measured by 6-thioguanine resistance is higher in male than in female Syrian hamster fetuses

✍ Paul J. Donovan; George T. Smith; Lee F. Dove; John Klose; Douglas A. Powell 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB

Morphology of tumors induced in Hamsters

Morphology of tumors induced in Hamsters by Simian adenoviruses

✍ I. S. Levenbook; A. E. Chigirinsky; E. M. Tsetlin; N. N. Dodonova; A. D. Altstei 📂 Article 📅 1968 🏛 John Wiley and Sons 🌐 French ⚖ 918 KB

Subcutaneous hamster tumors induced by Simian adenovirus SA7, strains C8, B105 and C626, were found to be poorly difJerentiated sarcomas having morphological features which distinguish them from tumors induced at the same site by papovaviruses and the Rous sarcoma virus. In general, the adenovirus-i

Breast tumors induced by N-methyl-N-nitr

Breast tumors induced by N-methyl-N-nitrosourea are damaging to bone strength, structure, and mineralization in the absence of metastasis in rats

✍ Matthew P Thorpe; Rudy J Valentine; Christopher J Moulton; Amy J Wagoner Johnson 📂 Article 📅 2011 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 757 KB

## Abstract Current theory on the influence of breast cancer on bone describes metastasis of tumor cells to bone tissue, followed by induction of osteoclasts and bone degradation. Tumor influences on bone health in pre‐ or nonmetastatic models are unknown. Female rats (__n__ = 48, 52 days old) were

Toxicological characterization of N-meth

Toxicological characterization of N-methyl-N-nitrosourea-induced cataract in rats by LC/MS-based metabonomic analysis

✍ Yuko Miyazono; Kazuo Harada; Koji Sugiyama; Motonobu Ueno; Mikinori Torii; Ikuo 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 641 KB

## Abstract Cataract is one of the most serious drug‐induced side effects that can terminate the development of drug candidates, and pharmaceutical companies consider it important to evaluate cataract‐inducing potential in the early phases. Metabonomics is expected to be a powerful approach for the