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Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance

✍ Scribed by Besim Ogretmen; Yusuf A. Hannun

Book ID
117836220
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
180 KB
Volume
4
Category
Article
ISSN
1368-7646

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## Abstract Multidrug resistance (MDR) mediated by the ATP‐dependent efflux protein P‐glycoprotein (P‐gp) is a major obstacle to the successful treatment of many cancers. In addition to effluxing toxins, P‐gp has been shown to protect tumor cells against caspase‐dependent apoptosis mediated by Fas