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Up-regulation of tumor suppressor genes might promote the malignant phenotype of cancer cells

✍ Scribed by Liu Hong; Xiaohua Li; Haifeng Jin; Li Yan; Kaichun Wu; Jie Ding; Yunping Zhao; Wei Guo; Daiming Fan

Book ID
116744027
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
31 KB
Volume
69
Category
Article
ISSN
0306-9877

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## Abstract Retinoic acid receptor B2 (__RARB2__) is frequently inactivated in cancer. Methylation in the 5′‐untranslated region and first exon is known to play a role; however, few studies have analyzed the detailed methylation pattern of the promoter region. We show that hypo‐ and hypermethylated