In human cancers, the co-operative role between celladhesion receptors and proteases capable of degrading matrix barriers remains poorly understood. We have previously reported that the epithelium-restricted integrin ␣v6 becomes highly expressed in colon cancer compared with normal mucosa and that
✦ LIBER ✦
Up-regulation of the α6β4 integrin in human colon cancer cells
✍ Scribed by Hehong Ni; David Gagne; Nuria Basora; Jean-Francois Beaulieu
- Book ID
- 119429167
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 192 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0016-5085
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## Abstract We have previously reported that the αvβ6 integrin upregulates its own expression in a protein kinase C‐dependent manner with increasing cell density. The wild‐type β6 integrin subunit has also been shown to promote tumour growth __in vivo__ and its growth‐enhancing effect is regulated
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