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The αvβ6 integrin induces gelatinase B secretion in colon cancer cells

✍ Scribed by Michael Agrez; Xinhua Gu; Jacqueline Turton; Cliff Meldrum; Jun Niu; Toni Antalis; Eric W. Howard

Publisher
John Wiley and Sons
Year
1999
Tongue
French
Weight
198 KB
Volume
81
Category
Article
ISSN
0020-7136

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✦ Synopsis

In human cancers, the co-operative role between celladhesion receptors and proteases capable of degrading matrix barriers remains poorly understood. We have previously reported that the epithelium-restricted integrin ␣v␤6 becomes highly expressed in colon cancer compared with normal mucosa and that heterologous expression of ␣v␤6 in colon cancer cells is associated with enhanced cell growth. Herein, we report that ␣v␤6 expression in colon cancer cells leads to a relative increase in secretion of the matrix metalloproteinase gelatinase B over its respective inhibitor and that this secretion parallels the level of cell-surface ␤6 expression. The ␣v␤6-mediated gelatinase B secretion is associated with increased proteolysis of denatured collagen at the cell surface, and inactivation of gelatinase B in ␤6-expressing tumour cells inhibits cell spreading and proliferation within 3-dimensional collagen matrices. Our findings suggest that ␣v␤6mediated gelatinase B secretion is important in the progression of human colon cancer. Int.

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