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Up-regulation of signal transducer and activator of transcription-3 is associated with aggravation of ulcerative colitis

โœ Scribed by Fujun LI; Yiyou ZOU; Xuefeng LI


Book ID
119374463
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
446 KB
Volume
8
Category
Article
ISSN
1479-666X

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We have demonstrated that constitutive signal transducer and activator of transcription (STAT) 3 activity, observed in approximately 50% of acute myeloid leukemia (AML) cases, is associated with adverse treatment outcome. Constitutive STAT3 activation may result from the expression of oncogenic prot