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Epigenetic regulation of signal transducer and activator of transcription 3 in acute myeloid leukemia

✍ Scribed by Sampa Ghoshal (Gupta); Heinz Baumann; Meir Wetzler

Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
350 KB
Volume
32
Category
Article
ISSN
0145-2126

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✦ Synopsis

We have demonstrated that constitutive signal transducer and activator of transcription (STAT) 3 activity, observed in approximately 50% of acute myeloid leukemia (AML) cases, is associated with adverse treatment outcome. Constitutive STAT3 activation may result from the expression of oncogenic protein tyrosine kinases or from autocrine stimulation by hematopoietic growth factors. These causes are generally neither necessary nor sufficient for leukemogenesis; additional transforming events or growth stimulatory processes are needed. Here we review the literature addressing epigenetic regulation as a mechanism controlling STAT3 signaling in AML. A better understanding of mechanisms of dysregulation of STAT signaling pathways may serve as a basis for designing novel therapeutic strategies that target these pathways in leukemia cells.

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