Up-Regulation of p21WAF1 by Phorbol Ester and Calcium in Human Keratinocytes through a Protein Kinase C-Dependent Pathway
β Scribed by Carole Todd; Nicholas J. Reynolds
- Book ID
- 117022781
- Publisher
- American Society for Investigative Pathology
- Year
- 1998
- Tongue
- English
- Weight
- 573 KB
- Volume
- 153
- Category
- Article
- ISSN
- 0002-9440
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Using a calpain/protein kinase C (PKC) complex, we were able to reproduce, __in vitro__, the induction of PKC downβregulation by the phorbol ester 12βOβtetradecanoylβphorbolβ13βacetate (TPA) which had been previously observed in cells. We show that TPA initiates this phenomenon by promo
The signal transduction mechanism of protein kinase FA/GSK-3a by tyrosine phosphorylation in A431 cells was investigated using calphostin C as an inhibitor for protein kinase C (PKC). Kinase F A / C S K -~~ could be tyrosine-dephosphorylated and inactivated to -10% of control in a concentration-depe