IL-1-induced ERK1/2 activation up-regulates p21Waf1/Cip1 protein by inhibition of degradation via ubiquitin-independent pathway in human melanoma cells A375

Up-regulation of p21CIP1 expression medi

Up-regulation of p21CIP1 expression mediated by ERK-dependent and -independent pathways contributes to hepatocyte growth factor-induced inhibition of HepG2 hepatoma cell proliferation

✍ Erika Shirako; Naoki Hirayama; Yu-ichi Tsukada; Toshiaki Tanaka; Naomi Kitamura 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 358 KB 👁 2 views

## Abstract Strong activation of the ERK signal is required for hepatocyte growth factor (HGF) to inhibit proliferation of the human hepatocellular carcinoma cell line HepG2. However, it is still to be elucidated whether the activation alone is sufficient to induce the inhibitory effect. In this st