Up-regulation of glial cell line-derived neurotrophic factor (GDNF) expression in regenerating muscle fibers in neuromuscular diseases
β Scribed by Hidenori Suzuki; Asako Hase; Bong Yoon Kim; Yuhei Miyata; Ikuya Nonaka; Kiichi Arahata; Chihiro Akazawaa
- Book ID
- 117477198
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 167 KB
- Volume
- 257
- Category
- Article
- ISSN
- 0304-3940
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Human SK-N-AS neuroblastoma and U-87MG glioblastoma cell lines were found to secrete relatively high levels of glial cell line-derived neurotrophic factor (GDNF). In response to growth factors, cytokines, and pharmacophores, the two cell lines differentially regulated GDNF release. A 24-hr exposure
Glial cell line-derived neurotrophic factor (GDNF) has been shown to exert neurotrophic effects on motor neurons as well as mesencephalic dopaminergic neurons. Because GDNF promotes survival of motor neurons in vivo and in vitro and rescues motor neurons from naturally occurring cell death, the pote