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Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina

✍ Scribed by Mei Chen; Elizabeth Muckersie; Marie Robertson; John V. Forrester; Heping Xu

Book ID
116456808
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
763 KB
Volume
87
Category
Article
ISSN
0014-4835

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## Abstract One of the earliest signs of age‐related macular degeneration (AMD) is the formation of drusen which are extracellular deposits beneath the retinal pigmented epithelium (RPE). To investigate the relationship between drusen and AMD, we focused on amyloid Ξ² (AΞ²), a major component of drus