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Unusual solubility and dissolution behavior of pharmaceutical hydrochloride salts in chloride-containing media

โœ Scribed by Shozo, Miyazaki; Midori, Oshiba; Tanekazu, Nadai

Book ID
123499884
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
556 KB
Volume
6
Category
Article
ISSN
0378-5173

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The pH-solubility profile of phenazopyridine as determined by the addition of HCl or NaOH solutions to its aqueous suspension was identical to that of its hydrochloride salt except during phase transition from base to salt. With the addition of HCl to a suspension of the base, the pH dropped to a ce