reported on a four-generation family with an unusual segregation pattern involving a translocation t(lO;l6)(q26.3;pl3.1). All relatives either had a balanced or unbalanced translocation. We report on five additional relatives, none of whom have a normal karyotype. This unusual segregation pattern ma
Unusual segregation in a family with a 11/21 translocation
โ Scribed by Pernille Steensen; Judith Helen Ford; Kaj Lillquist; Ursula Friedrich
- Book ID
- 115089824
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 393 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0009-9163
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Two sisters are described, each with a specific retardation syndrome due to a balanced reciprocal translocation 9p;21q in the mother. As a result of different 3:1 segregations, one of them has a trisomy 9p with all typical features; the other one reveals a typical Down's syndrome having an unusual t
We have used Y-specific and Y-derived DNA probes for in situ hybridization and Southern blotting analysis to characterize a Y;15 translocation showing normal Mendelian inheritance in a family. Cytogenetically there appeared to be an unbalanced translocation of Yqh to 15p; this translocation may be c