Design and Synthesis of 1,4-Diazabicyclo[4.3.0]nonane Peptidomimetic Endothelin Antagonists. -Four peptidomimetics such as (XI) are synthesized in order to examine the effect of the carboxyl group stereochemistry on the biological activity. The structures of the peptidomimetics are based on the pep
Unusual Rearrangement of Spiro β-Lactams to 1,4-Diazabicyclo[4,4,0]decanes and 1,4-Diazabicyclo[4,3,0]nonanes. Synthesis of Conformationally Restricted σ-Receptor Ligands.
✍ Scribed by Alberto Macias; Eduardo Alonso; Carlos del Pozo; Javier Gonzalez
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 99 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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The synthesis of a new series of 1 beta-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octane-2,4-dione moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bateria are determined and the effect of substituent on the bicyclic ring as well as st
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