Unusual Ph translocations in CML: Four new cases
✍ Scribed by M. Sessarego; F. Ajmar; G.L. Bianchi Scarrà; R. Ravazzolo; C. Garré; P. Boccaccio
- Book ID
- 119103059
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 558 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0165-4608
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A 63-year-old woman with Ph1-positive CML and a constitutional 13;14 Robertsonian translocation is described. The rarity of this cytogenetic combination and the significance of the D/D translocation in the genesis of the Ph1 and other chromosome anomalies in myeloproliferative disorders is briefly d
A proportion of cases of chronic myelogenous leukaemia (CML) has been described either (1) with a variant translocation, or (2) without the apparent involvement of both 9q34 and 22qll (Ph-negative CML). All variant translocations have been further demonstrated to be complex implicating 9q34,22q11, p