Clonal chromosomal evolution was observed in a 16-year-old boy suffering from Ph1-positive CML. An isodicentric Ph1 chromosome appeared 20 weeks after the initial diagnosis. At that time an allogeneic bone marrow transplantation was performed. Thereafter, during an observation period of more than 13
Ph1-positive CML in a 13;14 translocation carrier
β Scribed by Kohno, Sei-Ichi ;Sandberg, Avery A.
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 209 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0098-1532
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β¦ Synopsis
A 63-year-old woman with Ph1-positive CML and a constitutional 13;14 Robertsonian translocation is described. The rarity of this cytogenetic combination and the significance of the D/D translocation in the genesis of the Ph1 and other chromosome anomalies in myeloproliferative disorders is briefly discussed. It is concluded that the occurrence of the two cytogenetic anomalies and the clinical states is coincidental.
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