Unusual mode of alkylation of certain ketone dianions
โ Scribed by Trimitsis, G. B.; Hinkley, J. M.; TenBrink, R.; Poli, M.; Gustafson, G.; Erdman, J.; Rop, D.
- Book ID
- 127310837
- Publisher
- American Chemical Society
- Year
- 1977
- Tongue
- English
- Weight
- 428 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
In contrast to an earlier report, aldoximes can be deprotonated to their dianions and alkylated in high yield. In 1976, Kofronl and JungL reported that ketone oximes could be deprotonated and alkylated regiospecifically syn to the oxime hydroxyl. In his report, Kofron noted that "attempts to alkyla
Several years ago Hauser observed that treatment of aromatic ketoximes with two equivalents of strong base resulted in the formation of dianions which could be successfully alkylated on n carbon.L However, no information on the stereochemistry of the alkylated products was ever reported. We now wish