The formation and alkylation of ฮฑ-ketoam
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Emil R Koft; Michael D Williams
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Article
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1986
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Elsevier Science
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French
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Alpha ketoamides may be deprotonated twice with stronq base. The dianions so formed react with alkyl halides to yield cl-amid0 tertiary alcohols. The extended enolates of crotonic acid derivatives 'anb have become valuable reactive intermediates in the preparation of R,y-unsaturated carbonyl compou