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Unusual cytogenetics in a case of acute lymphoblastic leukemia

✍ Scribed by Morse, Helvise G. ;Hays, Taru ;Odom, Lorrie F.

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
268 KB
Volume
7
Category
Article
ISSN
0098-1532

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✦ Synopsis

The cytogenetics in the study of a patient with acute lymphoblastic leukemia are presented. Initially, a large proportion of both unstimulated and phytohemagglutinin (PHA)-stimulated blood mitoses showed an abnormal karyotype with a 7;12 translocation and a trisomy 19. At the time of relapse, a PHA-stimulated culture showed the clonal abnormality as well as dicentric chromosomes in normal cells, the latter possibly resulting from treatment.

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