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Unstable amplification of the chromosomal gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase in compactin-resistant CR200 cells

โœ Scribed by Keiji Hasumi; Shin Naganuma; Yasuhiro Sato; Akira Endo


Book ID
115740644
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
501 KB
Volume
1083
Category
Article
ISSN
0005-2760

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We have used a cDNA clone for Chinese hamster 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase to isolate a genomic recombinant for human HMG-CoA reductase. The identity of the gene was confirmed by partial sequence analysis. Several unique fragments that will be useful for restriction frag