Second generation analogs of rigid 6,7-s
β
Christos I. Stathakis; Ioannis Mavridis; Georgia Kythreoti; Athanasios Papakyria
π
Article
π
2010
π
Elsevier Science
π
English
β 695 KB
Previous work from our group described the synthesis and biological evaluation of new rigid, 6,6- and 6,7-spiro aminoglycosidic scaffolds targeting the bacterial ribosome. Herein we describe an improved synthetic protocol for their construction, and extend our study by further amino-functionalizatio