✦ LIBER ✦
Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome
✍ Scribed by Christos I. Stathakis; Ioannis Mavridis; Georgia Kythreoti; Athanasios Papakyriakou; Ioannis A. Katsoulis; Thomas Cottin; Panoula Anastasopoulou; Dionisios Vourloumis
- Book ID
- 104004974
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 695 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
✦ Synopsis
Previous work from our group described the synthesis and biological evaluation of new rigid, 6,6- and 6,7-spiro aminoglycosidic scaffolds targeting the bacterial ribosome. Herein we describe an improved synthetic protocol for their construction, and extend our study by further amino-functionalization of their 6,7-spiro analogs. The synthetic strategy, preparation and evaluation of some representative examples are reported.