Natural killer (NK) cell function in relation t o immunophenotypical signs of NK activation was studied prospectively in 15 renal transplant patients with cytomegalovirus (CMV) infection. NK activity (expressed as the percentage of K562 ly- sis) before onset of CMV infection reached a median of 6% (
'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection
β Scribed by Orr, Mark T; Murphy, William J; Lanier, Lewis L
- Book ID
- 109920852
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 583 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1529-2908
- DOI
- 10.1038/ni.1849
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Peripheral blood lymphocytes (PBL) from two human cytomegalovirus (CMV)-seronegative donors and eight CMV-seropositive donors were cultured for 3 days with or without the biological response modifier OK-432 and examined for lysis of K562 cells and CMV-infected MRC-5 cells. OK-432-stimulated PBL exhi
## Abstract Monoclonal antibody to the NK 1.1 antigen, found on the natural killer cells of a number of strains of mice, specifically suppresses NK cell function when given in vivo. Using this monoclonal antibody, we have examined the effects of specific suppression of natural killer (NK) cells in