Unique complex between bacterial azurin and tumor-suppressor protein p53
β Scribed by David Apiyo; Pernilla Wittung-Stafshede
- Book ID
- 116290636
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 139 KB
- Volume
- 332
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
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## Abstract It is known that the half life of the tumor suppressor p53 can be increased by the interaction with the bacterial protein azurin, resulting in an enhanced antiβtumoral activity. The understanding of the molecular mechanisms on the basis of this phenomenon can open the way to new antiβca
## Abstract p53 is a human tumour suppressor which regulates multiple cellular processes, including cell growth, genomic stability and cell death. Recent works have demonstrated the bacterial redox protein azurin to enter cancer cells and induce apoptosis through p53 stabilization, resulting in a t