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Unique binding pocket for KW-4679 in the histamine H1 receptor

✍ Scribed by Hiromi Nonaka; Shizuo Otaki; Etsuo Ohshima; Motomichi Kono; Hiroshi Kase; Kazumi Ohta; Hiroyuki Fukui; Michio Ichimura


Book ID
119414427
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
148 KB
Volume
345
Category
Article
ISSN
0014-2999

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Several phenylhistamines and histaprodifens were identified to act as (partial) agonists at the histamine H1 -receptor (H1 R). The large diversity of these compounds led to pKi values in a range between 4.5-7.5 at human, rat, bovine and guinea-pig histamine H1 R. Hybrid molecules, consisting of two