𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Solid-State NMR Evidence for a Protonation Switch in the Binding Pocket of the H1 Receptor upon Binding of the Agonist Histamine

✍ Scribed by Ratnala, Venkata R. P.; Kiihne, Suzanne R.; Buda, Francesco; Leurs, Rob; de Groot, Huub J. M.; DeGrip, Willem J.


Book ID
120069513
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
228 KB
Volume
129
Category
Article
ISSN
0002-7863

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


3D-QSAR CoMFA Study to Predict Orientati
✍ Andrea Straßer; Hans-Joachim Wittmann πŸ“‚ Article πŸ“… 2010 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 608 KB

Several phenylhistamines and histaprodifens were identified to act as (partial) agonists at the histamine H1 -receptor (H1 R). The large diversity of these compounds led to pKi values in a range between 4.5-7.5 at human, rat, bovine and guinea-pig histamine H1 R. Hybrid molecules, consisting of two