✦ LIBER ✦

Unicolor and bicolor in situ hybridization in the diagnosis of peripheral neuroepithelioma and related tumors

✍ Scribed by C. Desmaze; J. Zucman; O. Delattre; G. Thomas; A. Aurias

Book ID: 102221138
Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 496 KB
Volume: 5
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870050105

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✦ Synopsis

Abstract

The chromosome 22 breakpoint of the t(11;22) translocation of peripheral neuroepithelioma has been located, by fluorescence in situ hybridization, in the proximity of the interface between 22q12.1 and 22q12.2. Use of single cosmids or pools of cosmids of the flanking regions enables the monitoring of the translocation in interphase and in metaphase chromosomes. This method can now be routinely applied for the diagnosis of this translocation in mixed round cell tumors.

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