✦ LIBER ✦

Unexpected high serum levels of tacrolimus after a single topical application in an infant

✍ Scribed by Genn Kameda; Christof Kramm; Tim Niehues; Helger Stege; Derik Hermsen; Jean Krutmann

Book ID: 117849814
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 45 KB
Volume: 143
Category: Article
ISSN: 1097-6833
DOI: 10.1067/s0022-3476(03)00251-8

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Toxic serum levels of tacrolimus after t

Toxic serum levels of tacrolimus after topical administration in an infant with severe cutaneous graft-versus-host disease

✍ Prot-Labarthe, S; Therrien, R; Champagne, M A; Duval, M; Joubert, C 📂 Article 📅 2007 🏛 Nature Publishing Group 🌐 English ⚖ 72 KB

Transient sirolimus serum levels after i

Transient sirolimus serum levels after implantation of a sirolimus eluting stent in an infant

✍ Frank-Thomas Riede; Peter Schneider; Ingo Dähnert 📂 Article 📅 2007 🏛 Springer 🌐 English ⚖ 161 KB

Serum Tocopherol Levels in Very Preterm

Serum Tocopherol Levels in Very Preterm Infants After a Single Dose of Vitamin E at Birth

✍ Bell, E. F.; Hansen, N. I.; Brion, L. P.; Ehrenkranz, R. A.; Kennedy, K. A.; Wal 📂 Article 📅 2013 🏛 American Academy of Pediatrics 🌐 English ⚖ 905 KB

I: A bioavailability comparison in rabbi

I: A bioavailability comparison in rabbits after a single topical ocular application of prednisolone acetate formulated as a high-viscosity gel and as an aqueous suspension

✍ Johansen, Sven ;Prause, Jan Ulrik ;Rask-Pedersen, Eva 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 484 KB

II. An ocular bioavailability comparison

II. An ocular bioavailability comparison in rabbits of prednisolone acetate after repeated topical applications formulated as a high-viscosity gel and as an aqueous suspension

✍ Johansen, Sven ;Prause, Jan Ulrik ;Rask-Pedersen, Eva 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 503 KB

Saliva and serum samples were collected

Saliva and serum samples were collected from eight healthy volunteers every two hours during a 26-hour period. Melatonin concentrations were measured by radioimmunoassay after chloroform extraction using radioiodinated melatonin as a tracer. Five of the subjects had high serum melatonin levels at night (peak levels higher than 75 pg/ml); in three subjects the highest serum melatonin concentration was 20-40 pg/ml. All subjects had low levels (P <0.001, was obtained for all detectable value pairs (n= 73). The regression and correlation coefficients were almost equal for the peak values of melatonin and during the rising and descending phases of the secretion patterns. However, no significant correlation was found between low daytime salivary and serum concentrations when calculated separately. In the five high-secretors the melatonin levels in saliva reflected reliably the changes in serum, but in the three low-secretors the correlation between salivary and serum melatonin was not significant. The proportion of melatonin found in saliva decreased with increasing serum melatonin levels. Circadian rhythm parameters were estimated by single cosinor analysis. The acrophases did not differ significantly within a subject in the concomitant measurements of serum and salivary melatonin. The measurements of salivary melatonin levels seem valid for studies on melatonin rhythms, but the melatonin concentrations measured in saliva do not always consistently reflect the absolute concentrations in blood.

✍ Maija-Liisa Laakso; Tarja Porkka-Heiskanen; Aino Alila; Dag Stenberg; Gunnar Joh 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 622 KB