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Unexpected E-stereoselective reductive A3-coupling reaction of terminal alkynes with aldehydes and amines

โœ Scribed by Fan, Wu; Yuan, Weiming; Ma, Shengming


Book ID
121865220
Publisher
Nature Publishing Group
Year
2014
Tongue
English
Weight
462 KB
Volume
5
Category
Article
ISSN
2041-1723

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Sonogashira cross-coupling reaction of 3
โœ Anca Arnautu; Valรฉrie Collot; Javier Calvo Ros; Carole Alayrac; Bernhard Witulsk ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 195 KB

This paper describes a Sonogashira-type cross-coupling reaction of 3-iodoindazoles with various terminal alkynes as a general route to 3-alkynylindazoles. The coupling reaction is illustrated by the preparation of new indazolylpropiolic or propargylic derivatives. Scope and limitation of the method